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hES-MSCs cultured at a higher density (5 10 3 cells/cm 2 ) had increased GSH levels compared to those cultured at a lower density (2 10 3 cells/cm 2 ), confirming that GSH levels varied depending on the cell culture density (Fig

Evidence snapshot: The strongest human evidence comes from a 2-year randomized controlled trial in 65 healthy older adults (Nass et al., 2008, Annals of Internal Medicine) showing sustained GH/IGF-1 increases and preserved fat-free mass, plus an earlier short-term human polysomnography study on sleep (Copinschi et al., 1997, Neuroendocrinology, PMID 9349662)

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Results: Up to date 32 patients had been included in the intervention group and 21 completed 3 months follow up

The experiments with the ESCs also illuminated the fact that PDFV increases migration and invasion of ESCs