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ACSL4 is responsible for the esterification of CoA to free fatty acids in an ATP dependent manner, and then AA- and AdA-containing PE species are the preferred substrates for oxidation

They are called the porphyrias because they cause a build up of chemicals called porphyrins (the purple-red pigments named from the Greek for purple), or the simpler chemicals used by the body to make porphyrins

coli to investigate their effects on GSH production, including the reduction of l-cysteine degradation, manipulation of the glucose storage pathway, and elimination of the biological degradation of GSH (Fig

S6, S7)

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