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Proc Natl Acad Sci USA 118(52)

The accumulation of M1 macrophages triggers activation of JNK and IKK pathways through pattern-recognition receptor engagement, promoting insulin resistance through stress kinase signaling mechanisms (69, 70)

[DOI] [PubMed] [Google Scholar] 24.Hossain M.A., Hossain M.Z., Fujita M

34 The dynamic shuttling of lactate between the muscles and liver, facilitated by vascular connections, underscores its crucial role in metabolic homeostasis