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Nutritional deficiencies are the most common culprit particularly iron deficiency, vitamin B12 deficiency, and folate (vitamin B9) deficiency

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Consequences of untreated vitamin B12 deficiency among metformin users include a statistically significant increase in peripheral neuropathy with an odds ratio of 1.65, compounded by the increase in methylmalonic acid (MMA), along with jaundice and macrocytic anemia.[7,8] It is also crucial to pay attention to other symptoms of vitamin B12 deficiency that would be observable during a physical exam: glossitis, diarrhea, headaches, and neuropsychiatric disturbances.[9] The question is: who gets screened, and what are the guidelines

Engaging in light physical activity can further enhance circulation and nutrient distribution

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