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In vitro cross-species DILI assays also support 3Rs objectives and ethical considerations

Thromboxane synthase then converts prostaglandin H 2 into thromboxane A 2

doi: 10.4049/jimmunol.1202215 144 YangS

Aeroquin exhibit a good degree of tolerance in patients treated with the antibiotic with respect to placebo, and is currently being studied in phase III of clinical trials (Ballmann et al., 2012)

Under normal physiological conditions, NRF2 is extremely unstable, can be ubiquitinated by Kelch-like ECH-associated protein 1 (KEAP1), and is rapidly degraded by the proteasome pathway