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The complexity of multi-ingredient formulations makes it challenging to attribute specific outcomes to individual components

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5.3.2 Development of novel drugs Mitochondrial dysfunction is a central pathological feature of DCM, and developing drugs that restore mitochondrial function holds significant therapeutic potential (198)

Transient exposure to hypoxia, as may occur in tumors because of fluctuations in blood flow, may stimulate the amplification of genes, including those encoding DHFR, which leads to resistance to methotrexate (see Fig