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By directly binding to SLC7A11, recombinant human autophagy effector protein (BECN1) inhibits the activity of system x c , promotes GSH consumption and lipid peroxidation, and induces ferroptosis in cancer cells [137]

C.ReddyA

In the aspect of autophagy and the Nrf2-Keap1 antioxidant pathway, SQSTM1, TFEB, Sestrin2, and TRIM16 are all involved in different conditions and act as the scaffolds connecting the two pathways (Table 1)