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In an orthotopic glioblastoma mouse model, PTX-CDs accumulated within intracranial tumours and exerted antitumour effects through ROS-mediated oxidative stress [145]

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28 , 29 On the other hand, this lead Selye to propose the concept that the most essential role of the adrenotropic principle in the coping response was to reestablish homeostasis 22 while two other principles, thyrotropic and histaminergic, remained less emphasized