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Description

The HMP pathway is the only RBC source of reduced nicotinamide adenine dinucleotide phosphate (NADPH), a cofactor important in glutathione metabolism

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For example, the U87-MG glioma that was found resistant to CR when grown as a subcutaneous xenograft in NOD-SCID mice 63 was responsive to CR when grown orthotopically in mice of a different genetic background