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GPCR/MAPK Signaling cascades downstream of binding to GPCRs are also implicated in CIPN ( 1 and B 2 GPCRs either systemically (intraperitoneally) or only centrally (ICV), suggesting a role of these GPCRs in the CNS in modulating CIPN (Toyama et al., 2017)

Furthermore, a reduction in symbiotic bacteria such as Faecalibacterium prausnitzii and overgrowth of pathogenic bacteria have been observed in the gut of IBD patients, with host-associated gene mutations impairing the recognition and clearance of the gut microbiome

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These areas include the abdomen , flanks , thighs , chin , arms , love handles , and back

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JMD 15 , 895 (2013)