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In this review article, we aimed to update the understanding of the possible roles of HDACs in the pathophysiology of epilepsy, discuss the likely regulatory mechanisms of these enzymes and summarize the recent progress in the development of HDACi in epilepsy rodent models and patients

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Utilizing adjuvants to block detoxifying enzymes shown in curcumin metabolism is one of the most important methods for enhancing the oral bioavailability of curcumin ( Several adjuvants have been employed to enhance curcumins oral bioavailability for various therapeutic uses, including cancer

This MnCu axis highlights a general principle for metal ion interactions: the phenotypic outcomes are often dictated less by the total metal content than by metal speciation, subcellular redox control, and the capacity of cellular ligands to sequester and detoxify reactive metal pools