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6 Monoclonal antibodies directed against this protein are associated with multiple mechanisms of action that can attack the multiple myeloma cells, and two agents have been approved in the treatment of patients with multiple myeloma: daratumumab and isatuximab

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Both DARA and ISA enhanced cADPR-Hydrolase activity, increasing mean ADPR peak areas from the IgG1 control value (12.08 2.00) to comparable levels (16.91 1.60 and 16.30 2.20, respectively) (inset, Figure 3D )

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