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When this reservoir is low, you might feel more fatigued

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The HK reaction is one of two rate-limiting steps in this pathway, the other being the phosphofructokinase reaction

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It also upregulates cardiac-enriched microRNAs, creating a vicious cycle involving abnormal myosin heavy chain expression, autophagy inhibition, and impaired mitochondrial fatty acid oxidation (lvarez et al., 2023)

Li Q, Wu T, Liu R et al (2017) Soluble dietary fiber reduces trimethylamine metabolism via gut microbiota and co-regulates host AMPK pathways