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Synthesizing these findings, we outline emerging combination strategies that concurrently target ferroptosis and cuproptosis, and discuss current challenges and future directions for translating these concepts into precision therapies for OSCC

For example, administration of TGF neutralizing antibodies appeared to promote excessive monocyte-macrophage infiltration within murine and rat AAA tissue 29,73 , while overexpression or administration of TGF1 significantly increased aortic wall collagen deposition 74 , and collagen synthesis in normal arteries 75 .Recent studies demonstrated that TGF content is reduced in human AAA tissue 76 , and ketosis promoted TGF-induced myocardial fibrosis and Collagen 1 and 3 deposition in spontaneously hypertensive rats 77

Cells undergoing ferroptosis have different morphological and metabolic characteristics from other known forms of cell death (such as apoptosis, necrotizing apoptosis, and pyroptosis) [15]

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S, t=4.317, df=10, p=0.002 ), glutamine (K, t=2.200, df=10, p=0.026