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For more noticeable changes, a consistent series of treatments is recommended

10.1038/nature05862 Nature 211 RouloisD.Loo YauH.SinghaniaR.WangY.DaneshA.ShenS

doi: 10.3389/fmicb.2025.1688325 Received 19 August 2025 Accepted 23 October 2025 Published 11 November 2025 Volume 16 - 2025 Edited by Laura Mitrea, University of Agricultural Sciences and Veterinary Medicine of Cluj-Napoca, Romania Reviewed by Chen Ye, Tongji University, China Wu Yuqi, Microbiota I-Center Limited, Hong Kong SAR, China Updates Copyright 2025 Feng, Wang, Si, Lu, Lu, Gao, Yang, Wu, He and Wu

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While complete elimination of mature stretch marks is unlikely with any non-surgical treatment, GHK-Cu can visibly improve their appearance and texture over several cycles, particularly when combined with consistent topical application to the affected areas