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Duloxetine's FDA label specifically warns that "blood pressure should be measured prior to initiating treatment and periodically measured throughout treatment" [4]

Initially, with the entire dose at the absorption site (bucket, see Fig

The only meaningful comparison context is against the other agents in the class, covered in our Retatrutide vs Semaglutide vs Tirzepatide analysis, and the two entry points for the protocol itself are the 5 mg vial protocol for a gentle start and the 30 mg vial protocol for higher maintenance targets