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In clinical genetic practice, thus Clinical variants correspond to variants of uncertain significance (VUS) thought to be very likely to be a disease related as the reported phenotype for the gene closely matches the clinical phenotype of the patient (clinical correlation)

Conflicts of Interest The authors declare no conflicts of interest

This results in the formation of malate and the regeneration of residue Cys 290

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Table 1 shows the ingredients and nutritional contributions of the experimental diets