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doi: 10.7717/peerj.16748, PMID: [DOI] [PMC free article] [PubMed] [Google Scholar] 69

Consequently, hepatocytes attempt to repair cellular damage through increased autophagy and mitophagy, which ultimately fails [2]

The appeal of these agents stems from their capacity to modulate key pathophysiological contributors in atherosclerosis and heart failure, including oxidative stress, chronic vascular inflammation, endothelial dysfunction, dyslipidemia, and mitochondrial energy deficits (Virani et al., 2021)

The minimal clinically important difference threshold for weight loss in adults was considered as 5 % weight loss (Reference Shi, Wang and Hao21) , equal to 45 kg (Reference Shi, Wang and Hao22)