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Long term tolerance of aspartame by adult PKU heterozygotes

A twin study by Bremner et al (2021) suggested that individuals with higher serum levels of homocysteine exhibited increased self reported symptoms of depression, the study concluded that homocysteine may be correlated but not causative in the aetiology of depression

Moreover, PD patients generally have a defective antioxidant system, such as reduced activity of the cysteine/glutamic acid reverse transporter and reduced GSH levels (83, 84)

Incidentally, reduced nicotinamide adenine dinucleotide phosphate oxidase is considered to be the major source of superoxide generation

It can cause a lot of different signs, like tiredness, joint pain, muscle aches, and nerve problems