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Either approach appears capable of producing meaningful improvements based on available evidence and user reports

doi: 10.1016/S2213-2600(22)00159-X 177 OMahoneyLLRoutenAGilliesCEkezieWWelfordAZhangAet al

We have already developed an ADC by conjugating monomethyl auristatin F (MMAF) to the M25AD IgGl and demonstrated anti-tumor activity in vitro (Figure 2) and in vivo (Figure 3)

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Although the totality of the data supports the immune complex hypothesis described above, we cannot rule out an alternative or supplemental mechanism, such as binding of AMG 966 to TL1A and/or TNF on the surface of antigen presenting cells

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