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(1) Iron compartmentalization strategies contrast systemic chelators like DFO/DFX, which fail to cross the BBB, with membrane-permeable agents like DFP/TPP-chelators that specifically access mitochondrial iron deposits

There have been situations where some black women use natural remedies because of claims in some quarters that the natural meals they consume daily contain nutrients beneficial to the skin when applied directly

Preclinical studies have indicated the potential efficacy of this approach across a range of diseases, including ischemia-reperfusion injury, neurodegenerative disorders, kidney diseases, acute respiratory distress syndrome, and cancer [124, 138,139,140,141,142,143]

A guideline on the molecular ecosystem regulating ferroptosis

Neuroscience 143 , 911922 (2006)

This shows that hypertension leads to iron overload in the brain, and iron overload increases OS and lipid peroxidation, thereby causing ferroptosis (Yang et al., 2020) in neurons and ultimately leading to brain injury (Figure 2)