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Several studies on AD specimens and/or animal and cell culture models thereof describe the interaction between the alteration of key metabolic pathways and OS

Cephalalgia 27 , 304314 (2007)

Some, but not all, studies have reported that HIF activation can decrease the content of mitochondria in cells, which offers a plausible explanation for the known decrease in cellular respiration in response to hypoxia (Figure 2A)