Abbreviations AADvac-1 : Active immunotherapy vaccine-1 ACH : Amyloid-cascade hypothesis AD : Alzheimers disease ADDLs : A-derived diffusible ligands ADNP : Activity dependent neuroprotective protein : AP-90 Alzheimer Pathology 90 APH1 : Anterior pharynx defective 1 APLP1 and APLP2 : APP-like proteins 1 and 2 APP : Amyloid precursor protein ART : Amyloid reduction therapy A : Amyloid-beta AD : Amyloid dimer) AFs : Amyloid fibrils AM : Amyloid monomer AO : Amyloid oligomer APF : Amyloid protofibril BACE1 : Beta-site APP cleaving enzyme 1 BBB : Blood Brain Barrier : BiP Binding immunoglobulin protein Ca2 + -CaN : Calcineurin CAA : Cerebro-vasculature cdk-5 : Cyclin-dependent kinase CHC : Central hydrophobic core CNS : Central nervous system CSF : Cerebrospinal Fluid CTFs : C-terminal fragments Fc : Ferrocenoyl GAPDH : Glyceraldehyde-3-Phosphate Dehydrogenase GHK-Cu : Glycyl-L-histidyl-L-lysine Copper GHK-Cu : Glycyl-L-histidyl-L-lysine-copper GPE : Gly-Pro Glu GRP78 : Glucose-regulated protein 78 Gsk3 : Glycogen synthase kinase 3 HDACs : Histone deacetylase Hsp : Heat shock proteins iAb5p : Ac-Leu-Pro-Phe-PheAsp-NH2 IDE : Insulin Degrading Enzyme LRP1 : Lipoprotein receptor-related protein-1 MARK : Microtubule affinity-regulating kinase MMPs : Metalloproteinases NAP : Neuroprotective Peptide NF-kB : Nuclear Factor-kB NFTs : Neurofibrillary tangles NMDA : N-methyl-D-aspartate ODT : Oral disintegrating tablets PEN-2 : Presenilin enhancer 2 P-gP : P-glycoprotein PS1 : Presenilin 1 RAGE : Receptor for Advanced Glycation End-Products ROS : Reactive Oxygen Species) STEP : Striatal-enriched protein tyrosine phosphatase TFP5: Truncated 24-aa peptide tTG : Tissue transglutaminase : WT Wildtype References Aileen Funke S, Willbold D (2012) Peptides for therapy and diagnosis of Alzheimers disease
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N-Acetyl-p-benzoquinone imine (NAPQI), the toxic metabolite of APAP, besides its intrinsic ability to form aspecific chemical adducts with proteins, promotes the excessive accumulation of ROS mostly depleting the GSH pool that it is required for its detoxification
