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Cham (CH: Springer (2020)

806 The current clinical treatment of myocardial I/R injury is limited, but antioxidants and active substances from Chinese medicine have shown great potential

The ,-unsaturated enone moiety of resorcylic acid lactones is susceptible to Michael addition reaction with a conserved cysteine residue (Cys166 in human ERK2) (95)

Noda, H., Takeuchi, H., Mizuno, T

Increased susceptibility of eukaryotic cells to paraquat is indeed present in N

Results: TG-IRE1 mice treated with ip DOX for 4 hrs had a 2.6-fold increase in hepatic IRE1 gene expression (P 90% reduction in hepatic gene expression of Cyp7a1 from 1.13+/-0.63 to 0.1+/-0.06 (P 65 years appear less likely to undergo curative treatment, particularly liver transplantion, and experience higher hazards of mortality