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33,34 With growing evidence of the limitations of conventional pharmacological agents and a surge in functional GI disorders, there is renewed interest in these systems

Demonstrating improvements in lobular inflammation, hepatocellular ballooning, and fibrosisthe defining features of NASH progressionwill be essential to establish true therapeutic efficacy, rather than relying solely on serum biomarkers or liver enzyme reductions, which remain imperfect surrogates of histological benefit

doi: 10.1128/iai.69.6.4034-4040.2001 58 StoneKKBermudezEPryorWA

Before treatment, average TC was 5.03 1.10 mmol/L, and TG 2.34 1.99 mmol/L

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