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Interestingly, the ceramide apoptotic pathway in the tumour vascular endothelium, activated with ablative radiation doses, is thought to be especially important (Garcia-Barros et al., 2003

Compared to controls, ALS patient lower motor neurons exhibit significantly lower levels of these epigenetic markers, suggesting an association between TDP-43 and DNA methylation, while changes in glial cell methylation are minimal and primarily affect lower motor neurons (151)

Studerus E, Gamma A, Vollenweider FX

One is indeed Gsi and our data strongly suggests that its preferred substrate is oxidized and not reduced glutathione

doi: 10.1007/s00109-006-0093-x Zhai, Ting et al