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This shift is associated with reduced cellularity and significant thymus involution [167,168]

The nuclear interior houses chromatin and other subnuclear structure that plays an equally essential role in controlling cellular biological processes and determining mechanical properties (217)

Lipid peroxidation The cells were labeled via incubation with BODIPY 581/591 C11 dye (Thermo Fisher Scientific, USA) or Liperfluo dye (Dojindo, China) for 30 min at 37 C

Crystal structures of a truncated hOGA lacking the C-terminal domain have revealed a homodimer, in which the helical stalk domain contributes to the dimer interface 17,18,19

However, when citrullination occurs, the positive charge of the arginine side chain is removed, and intermolecular interactions can be disrupted by altering hydrogen bonds and cation- interactions, ultimately inhibiting FUS phase separation

Brain Behav Immun (2017) 62:27790