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Although MIF shares low sequence homology with natural ligands, such as CXC motif chemokine ligand (CXCL8) and SDF-1 (CXCL12), it contains specific motifs that enable receptor binding upon protein folding

The multivalent synergistic effect of weak interactions between amino acid groups and other macromolecules, such as proteins and nucleic acids, contributes to the formation of phase separation 13,42,43,44,45,46,47,48

When oxidative stress occurs, it can lead to inflammation, fibrosis, and even cirrhosis over time

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Augmented viability and functional potency of MSCs Natural flavonoids can activate Nrf2 through direct or indirect mechanisms, thereby enhancing the antioxidant, anti-apoptotic, and anti-aging capacities as well as the differentiation potential of MSCs

Global Quantitative Proteomics analysis Tissue from mice with MG3 tumors placed on CMD or control diets as previously described was fixed at end-stage in 4% PFA and paraffin embedded