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Consistently, T-cell-specific transgenic mice expressing the dominant-negative DUSP22-C88S mutant also show T-cell hyperactivation, inflammation, and autoimmune nephritis [110]

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Induction of peroxynitrite activates volume-regulated anion channels in astrocytes and induces astrocytic swelling which was coupled to enhanced release of the glutamate surrogate [ 3 H]D-aspartate (Haskew et al., 2002)