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Central nervous system: seizure, CNS depression, low-grade coma, anxiety, anoxic brain damage (Exposure Dependent) Cardiovascular system: palpitation, mild hypertension, to life-threatening complications such as cardiopulmonary arrest Respiratory system: respiratory depression, resulting in slowed or shallow breathing, which may compromise oxygen delivery to the body

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One week after the last immunization, sneezing and nasal rubbing were assessed for 5 min after intranasal administration of 0.5 mg OVA (25 mg/ml OVA in 20 l PBS)