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79 (Suppl 1), 1311

Microglial cell dysregulation in brain aging and neurodegeneration

When taken within recommended dosages, side effects are rare

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They further modified DMB and developed inhibitors targeting CutC and CutD, the major microbial TMA-generating enzyme pair, and when administered as a single oral dose, significantly decreased plasma TMAO concentrations for up to 3 days and rescued the diet-induced enhancements in platelet reactivity and thrombosis in animal models, without increasing bleeding risk or toxicity (Roberts et al., 2018)