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The PL condition served as the control/baseline condition for the present study
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PATHOPHYSIOLOGY AND MECHANISMS Migraine is a complex and disabling neurological disorder, more prevalent in women, whose pathophysiology involves neurovascular mechanisms, mitochondrial dysfunction, neurogenic inflammation, and oxidative stress
436 Preclinical 69,434 and human genetic studies 69,437,438 in PDPN have shown evidence of enhanced function of voltage-gated sodium channels
Pateria, P., DeBoer, B., & MacQuillan, G