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Continued opioid use despite knowledge of having a persistent or recurrent physical or psychological problem that is likely to have been caused or exacerbated by the substance

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You may also be at risk if you take certain medications, such as proton pump inhibitors (Nexium, Prilosec, Prevacid), histamine-2 receptor agonists (Pepcid and Zantac), and metformin for type 2 diabetes

Imdelltras label contains a boxed warning for serious or life-threatening cytokine release syndrome and neurologic toxicity, including immune effector cell-associated neurotoxicity syndrome, according to the FDAs press release