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It is important to note that B12 injections should only be used when there is a diagnosed deficiency or clear clinical indication

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Concurrently, altered glucose metabolism in the orbitofrontal cortex and limbic regions reflects energy deficits and mitochondrial dysfunction, contributing to the severity of psychiatric symptoms, such as paranoia, agitation, and mood disturbances ( MRI studies have further identified gray matter atrophy in the prefrontal cortex, medial cingulate gyrus, and hippocampus, regions that are critically involved in memory, decision-making, and emotional regulation (Thompson et al., 2004)

Luis Calln Sevilla and Luis Palomera Bernal, heads of the hematology section, from the Hospital Clnico Universitario Lozano Blesa kindly provided advice and facilities for cobalamin measurements