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Measures assessed at initiation of biologic therapy included health-related quality of life, itch, pain, fatigue, psoriatic arthritis, psoriasis disease characteristics, and medical history

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It achieves this by cleaving the disulfide bonds that hold mucin glycoprotein polymers together

In summary, glutamine metabolism through both GLS isoforms was essential for maintaining TCA cycle metabolite levels, since inhibition with telaglenastat decreased the overall pool of all evaluated metabolites