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Although the contribution of dietary methionine excess (which increases folate, vitamin B 6 , and vitamin B 12 requirements) has not been clinically assessed, folate deficiency (associated or not with the thermolabile MTHFR mutation) and vitamin B 6 deficiency (associated or not with heterozygosity for CBS defects) could largely account for this increased risk of hyperhomocysteinemia-related cardiovascular disease

DAPK1 is a potential target for synaptic protection in HD, which can prevent the loss of striatum spines

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Before making the diagnosis of PFIC, in the paediatric population, other cholestasis disorders should always be considered in the differential diagnosis, including biliary atresia, choledochal malformations, congenital endocrine disorders, inborn errors of metabolism (mainly during the neonatal period) as well as autoimmune liver diseases, drug-induced cholestasis and other genetic diseases in older children [72]

Alterations in pleiotropic processes and pathways Hypoxia and the endoplasmic reticulum stress response Hypoxia Cells in solid tumors are exposed to hypoxic conditions, and extensive hypoxia is correlated with platinum resistance and tumor progression [55]

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