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A second cohort of mice including WT, RAMP1 KO, RAMP3 KO, and RAMP1/3 KO genotypes confirmed that both RAMP1 and RAMP3 are individually essential for a full cagrilintide-induced neuronal activation response

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These results were consistent with previous findings and highlighted the significance of N-myristylation of FSP1, which could target to the plasma membrane, induce NADH-dependent reduction of CoQ, and finally suppresses lipid peroxidation, the hallmark of ferroptosis

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