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Previous evidence has shown that adenosine is one of the neuromodulators involved in the pathophysiology of migraine (218)

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To protect the cell from a shift in the redox equilibrium, GSSG can be actively exported out of the cell or react with a protein sulfhydryl group leading to the formation of a mixed disulfide

Hence, melanocytes are one of the different types of cutaneous cells that contain massive amounts of ROS [13]

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