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Strategies to protect sensory hair cells rely on attenuating damaging effects by inhibiting one or more steps of ototoxic mechanisms

Heme binding protein genes (39 genes out of the studied 121 genes) were also enriched in the upregulated gene set (Additional file 2), however substantial transcriptional changes in the case of heme biosynthesis, Fe-S cluster assembly or Fe-S cluster protein genes were not observed (Additional file 2)

(2) Differentiate and accrete T cell and B cell and endow T cell with toxicity to kill virus and cancer cells

Further research is needed to elucidate the role of temperature in modulating IGF-1 action in bone and cartilage of mammals during development

Few studies have investigated these interactions, but additive protective effects have been observed when combining lithium with rapamycin or Keap1 inhibition in Drosophila models of HD and AD respectively (Sarkar et al., 2008