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Ko EY, Sabanegh ES Jr, Agarwal A

First, OS is involved in the development of diseases of the reproductive system, and it plays the role of a double-edged sword

Think of it as a delicate, high-tech piece of equipment

These lipid-soluble compounds are capable of crossing the blood-brain barrier, allowing them to exert direct neuroprotective and neuromodulatory effects within the central nervous system

Further studies are warranted in order to delineate the importance of circulating (endocrine) versus tissue (autocrine/paracrine) levels of IGF-1 in disease risk and progression