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In the CC (cation coordination) mutant (171179), residues equivalent to those coordinating Ca 2+ or Mg 2+ ions in -actin were deleted

However, even with an armamentarium of TNF inhibitors for physicians to choose from, most patients do not achieve this goal

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Termanis A, Torrea N, Culley J, Kerr A, Ramsahoye B, Stancheva I

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They may be traced to abnormal erythropoietin (EPO) sensitivity of erythroid precursors, abnormal EPO regulation, abnormalities intrinsic to mature red blood cells, and other etiologies