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The timepoint chosen (when drug-tolerant cells are emerging after treatment) probably contributes to this effect, and later timepoints (when cells perhaps enter senescence or other more terminally arrested states) are more likely to reflect the expected gene expression patterns

Recent positive selection drives the expansion of a schizophrenia risk nonsynonymous variant at SLC39A8 in Europeans

Therefore, addressing the dysregulated and often irreversible signaling pathways that promote fibrosis helps in developing effective therapeutic strategies [9]

Science 307 , 384387 (2005)

Methods Systematic searches were conducted to identify studies that would be suitable for this review

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