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Principal component analysis (PCA) of global expression profiles visualized this profound divergence ( Figure 3A )

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Danbolt, Niels Christian & Gundersen, Vidar (2011)

Loss of function of CAV1 cause Berardinelli-Seip congenital lipodystrophy and congenital generalized lipodystrophy type 3 (OMIM #612526), characterized by marked paucity of adipose tissue, extreme insulin resistance, hypertriglyceridemia, hepatic steatosis, and early onset of diabetes [43]