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Absorption quotient between the two assay conditions was calculated by the following equation: Absorption quotient (AQ) = (Papp, A-B with inhibitor - Papp, A-B without inhibitor)/Papp, A-B with inhibitor where Papp, A-B with inhibitor and Papp, A-B without inhibitor represent the apparent permeability of test compound from the apical to basal side of the cellular monolayer in the presence and absence of 10 P-gp inhibitor GF120918, respectively

Threonine 15 and 365 are important for UGT74F2 and UGT74F1 specificity, respectively Within the SA binding site, all residues are identical between UGT74F1 and UGT74F2 with the exception of position 15, which is a serine in UGT74F1 but threonine in UGT74F2 (Supplementary Fig