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Neuroinflammation and cytokine activation Chronic neuroinflammation is another driver of PD progression

Glutamate exerts its toxic effects through molecular pathways, which lead to neurodegeneration and cell death, for reviews see (Wang and Qin, 2010

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For instance, signaling through the Bad/p53 complex or the JNK-Bim axis promotes the conformational activation and translocation of Bax to the mitochondrial outer membrane