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It was found that the use of inhibitors of ferroptosis could reduce cigarette smoke-induced cell death, suggesting that ferroptosis plays an important role in cigarette smoke-induced trophoblast cell death and may contribute to miscarriage ( 5 Pathophysiological mechanism 5.1 Molecular mechanisms of ferroptosis Ferroptosis is a regulated form of cell death characterized by iron-dependent lipid peroxidation and oxidative stress, playing a significant role in RM through trophoblast dysfunction

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In the second stage, this radical intermediate, known as compound I, is reduced by a second hydrogen peroxide to regenerate the resting state enzyme, water and oxygen (reaction 3) [2, 3]

doi: 10.1007/s10072-017-3056-9

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