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Similarly, as an epigenetic regulator, lactate can directly participate in the regulation of gene expression through histone lactylation, a process that is dynamically modulated by enzymes such as acetyltransferase p300 and histone deacetylases (HDACs) [76, 77]

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elegans strains used in this work

However, the specific signaling pathways activated depend on the nature of the mechanical force applied, leading to distinct cellular responses

Zhang N, Hou L, Yan P

Vitamin B12 deficiency Having trouble absorbing vitamin B12 from food, lacking intrinsic factors (for example, as a result of pernicious anaemia), having gastrointestinal surgery, taking certain medications for an extended period of time (such as metformin or proton pump inhibitors), and nutritional deficiencies are all causes of vitamin B12 deficiency