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Mature human oligodendrocytes in the condition of being deprived from their myelin sheath may return into their previous subtype capacity and change their phenotype and their myelination program [37]

E., Betensky, R

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[45] (Additional file 1)

Additionally, CYP51A1 interacts with 15 core enzymes in the cholesterol biosynthesis pathway, including HMG-CoA reductase (HMGCR), FDFT1, dehydrocholesterol reductases (DHCRs), sigma non-opioid intracellular receptor 1 (SIGMAR1), and squalene epoxidase (SQLE), further supporting its central role in maintaining lipid homeostasis [47]