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Thompson KJ et al: Small intestinal microbial dysbiosis underlies symptoms associated with functional gastrointestinal disorders

In spinal cord tissues from patients with ALS, the expression of arachidonate 5-Lipoxygenase (ALOX5) and complement component 3 (C3) was markedly upregulated, accompanied by reduced GSH levels, elevated iron concentrations, and enhanced lipid peroxidation

PMID 9174360

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Several cell culture studies further confirm its role in the regulation of mucosal epithelial tight junction integrity