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Alternatively, the diagnostic criteria used to identify inadequate B12 status have been based on a known relationship between the serum B12 biomarker and low body stores, functional impairment, or clinical signs of deficiency

Research suggests that the combination of B12 with local anesthetics can be effective in treating myofascial pain syndrome while offering similar pain relief to corticosteroids

It also has shown effective for treatment of nerve pain, cancer, and high cholesterol

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Oxyntomodulin functions endogenously as a physiologic co-agonist, but regarding its small bioactivity, it is mainly characterized by its function as biosynthetic precursor to glucagon

Emerging animal studies also point to possible joint and cartilage benefits, particularly when paired with hyaluronic acid therapy